DAXXIFY. It's about time.
DAXXIFY. It's about time.

The long-lasting
frown line treatment

DAXXIFY™ is the only long-lasting, peptide-powered frown line treatment and the first innovation of its kind in over 20 years.
DAXXIFY logo
DAXXIFY patient wearing a yellow dress.
DAXXIFY patient wearing a yellow dress.

6-9 months of
smoother lines

DAXXIFY™ lasts on average 6 months and up to 9 months for some.*

*At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment. Between 3% and 5% of patients in clinical studies had no or minor frown lines 9 months after treatment. In other safety studies, between 5% and 17% of patients still had noticeable improvement 9 months later.

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OF AESTHETICS

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Frequently Asked Questions

DAXXIFY™ is FDA approved to help smooth moderate to severe lines between the brows. It is the only long-lasting frown line treatment powered by a peptide with results that last on average 6 months and up to 9 months for some.*

The active ingredient in DAXXIFY™ is a purified protein called botulinum toxin type A.

*At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment. Between 3% and 5% of patients in clinical studies had no or minor frown lines 9 months after treatment. In other safety studies, between 5% and 17% of patients still had noticeable improvement 9 months later.
Injectable wrinkle treatments containing botulinum toxin type A have been used to improve the look of moderate to severe frown lines for more than 20 years. The first FDA-approved treatment was BOTOX® Cosmetic, followed by Dysport®, Xeomin®, and Jeuveau®.

Although today’s wrinkle reducers all contain botulinum toxin type A, it’s important to know that no two treatments are alike and the doses cannot be interchanged with each other.
DAXXIFY™ is the only long-lasting frown line treatment powered by a peptide. Results last on average 6 months and up to 9 months for some.*

Other manufacturers use human serum albumin or cow’s milk protein to stabilize botulinum toxin type A, the active ingredient in injectable wrinkle treatments. DAXXIFY™ is the only formulation to contain a peptide and does not rely on human serum albumin or cow’s milk protein.

*At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment. Between 3% and 5% of patients in clinical studies had no or minor frown lines 9 months after treatment. In other safety studies, between 5% and 17% of patients still had noticeable improvement 9 months later.
All frown line treatments require a special ingredient to stabilize botulinum toxin A, the protein responsible for helping smooth moderate to severe frown lines. For instance, BOTOX® Cosmetic uses human serum albumin (HSA), a blood product, as its stabilizer. Dysport®, another frown line treatment, uses cow’s milk protein in addition to HSA.

DAXXIFY™ is unique because it is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.
DAXXIFY™ minimizes the appearance of moderate to severe frown lines by temporarily relaxing the underlying muscles that cause these wrinkles. DAXXIFY™ is a long-lasting botulinum toxin type A treatment with a novel peptide.

Facial fillers, also known as dermal fillers, are typically made of hyaluronic acid and are used to add volume, fullness, and structure to areas of the face. They can help contour cheekbones, soften lines around the nose and mouth, and volumize lips. Dermal fillers target volume loss rather than muscle-related wrinkles.
You may see results with DAXXIFY™ as early as the next day after treatment, and typically within two days.
Is your frown line treatment not lasting as long as you would like? If so, DAXXIFY™ could be the solution for you. Discuss your treatment goals with your aesthetic services provider. Click here to be the first to know when there’s an exclusive provider in your area.
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Botulinum toxins are biologics, produced from a bacterium called Clostridium botulinum. They are used to inhibit the transmission of specific chemical signals from nerves, primarily those signals that cause muscular contractions. Botulinum toxin type A injections temporarily relax the facial muscles that cause wrinkles between the brows, reducing their appearance.

DAXXIFY™ is the only FDA-approved, long-lasting frown line treatment (neuromodulator) to help smooth moderate to severe lines between the brows, lasting on average 6 months and up to 9 months in some.*

Injections of specific botulinum toxin formulations are also utilized in the treatment of medical conditions. *At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment. Between 3% and 5% of patients in clinical studies had no or minor frown lines 9 months after treatment. In other safety studies, between 5% and 17% of patients still had noticeable improvement 9 months later.
The safety and efficacy of DAXXIFY™ is well established, with more than 20 years of research. In fact, DAXXIFY™ has been studied in the largest ever phase 3 clinical trial program conducted for a frown line treatment and included more than 2,400 people across different ages and with different skin types. There were no notable differences in how DAXXIFY™ performed in clinical trial patients with varying skin types.
You may see results with DAXXIFY™ as early as the next day after treatment, and typically within two days. You should see noticeable results within a two-week time frame. You may experience mild injection-related bruising. In most cases, bruising heals within a few days after injection.
Ask your aesthetic provider for pre-treatment instructions prior to your DAXXIFY™ appointment.

A list of common avoidances before treatment include, but are not limited to:
  • Retin-A
  • Blood thinners
  • Muscle relaxants
  • Fish or oils rich in omega 3
  • Allergy medication
  • Topical steroids
  • Sleep medications and supplements
  • Aspirin
  • St. John’s Wort
  • Supplements containing Vitamin E
  • Ibuprofen
DAXXIFY™ injections are typically performed with a small needle, so you should only experience minimal discomfort during treatment. People treated with frown line treatments say the injection feels like a pinch.

There is a possibility that the area around the injection site will swell, turn red, and cause pain or tenderness from the injection itself; however, these side effects are typically very minor and go away after a few hours or days.
Several factors contribute to the formation of facial lines. Decreased collagen production, cellular changes, genetics, environmental damage, and sun damage may all play a role.

Facial lines are also formed by repeated muscle contractions such as frowning, squinting, or raising the eyebrows. These facial expressions cause the skin to furrow and fold, which eventually leads to the formation of wrinkles.

DAXXIFY™ works below the skin’s surface to temporarily reduce the underlying muscle activity responsible for moderate to severe frown lines.
DAXXIFY™ is manufactured in California, and the only prescription frown line treatment made in the United States. Conventional frown line treatments are manufactured in other countries, then imported into the United States.
In 2002, physicians and entrepreneurs founded a start-up in Silicon Valley, California to explore the use of peptides in biologics for different therapeutic uses. Their goal was to utilize peptides to transport biologics, typically large molecules, through the skin.

The initial idea was to formulate botulinum toxin type A, the active ingredient in DAXXIFY™, with a peptide to see if it could be applied topically to the skin to treat crow’s feet wrinkles. Through this process, scientists discovered that the formulation was optimally administered through injection. Several clinical studies were created to determine the correct dose for an injectable product that would treat frown lines.

In clinical studies, DAXXIFY™ lasted on average 6 months and up to 9 months for some people.* It is the only treatment of its kind formulated with a peptide.

*At least 50% of patients in clinical studies had no or minor frown lines 6 months after treatment. Between 3% and 5% of patients in clinical studies had no or minor frown lines 9 months after treatment. In other safety studies, between 5% and 17% of patients still had noticeable improvement 9 months later.

Important safety information for DAXXIFY™ (daxibotulinumtoxinA-Ianm) injection

DAXXIFY™ may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems any time (hours to weeks) after injection of DAXXIFY™:

Problems swallowing, speaking, or breathing due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.

• Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms that include: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing

Do not receive DAXXIFY™ if you: are allergic to any of the ingredients in DAXXIFY™ (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as rimabotulinumtoxinB (MYOBLOC®), onabotulinumtoxinA (BOTOX®/BOTOX Cosmetic®), abobotulinumtoxinA (DYSPORT®), incobotulinumtoxinA (XEOMIN®) or prabotulinumtoxinA-xvfs (JEUVEAU®); or have a skin infection at the planned injection site.

DAXXIFY™ dosing units are not the same as, or comparable to, any other botulinum toxin product.

Tell your healthcare provider about all your medical conditions, including: any side effects from botulinum toxin products, including dry eye; breathing, swallowing, bleeding, or heart problems; plans to have surgery; weakness of forehead muscles; drooping eyelids; have had surgery on your face; are pregnant or breastfeeding or plan to become pregnant or breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Using DAXXIFY™ with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your healthcare provider that you have received DAXXIFY™ in the past.

Especially tell your healthcare provider if you: have received any other botulinum toxin product in the last 4 months or any in the past, and exactly which product you received (such as BOTOX®, BOTOX Cosmetic®, MYOBLOC®, DYSPORT®, XEOMIN®, or JEUVEAU®). DAXXIFY™ may cause serious side effects, including: allergic reactions (such as itching, rash, redness, swelling, wheezing, trouble breathing, or dizziness or feeling faint) heart problems (such as irregular heartbeat and heart attack) and eye problems (including dry eye, reduced blinking, and corneal problems). Tell your healthcare provider or get medical help right away if you experience a serious side effect. No serious adverse events of distant spread of toxin effect associated with dermatologic use of DAXXIFY™ have been reported in clinical studies at the dose of 40 Units for glabellar lines. The most common side effects of DAXXIFY™ include: headache, eyelid drooping, loss of ability to move the muscles in your face.

These are not all the possible side effects of DAXXIFY™. For information see the full Prescribing Information Including Boxed Warning, and refer to the Medication Guide or talk with your doctor.

To report side effects associated with DAXXIFY™, please call 1-877-373-8669. You may also report side effects to FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

APPROVED USE: DAXXIFY™ is a prescription medicine that is injected into muscles and used in adults to temporarily improve the look of moderate to severe frown lines between the eyebrows.